What Is the Clomiphene Citrate Challenge Test?

What can I expect in the clomiphene citrate challenge test?
ByJohn Rinehart, MD, PhD, Reproductive Medicine Institute, Chicago
Fertility Specialist
Updated
Feb 2017
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Though not as widely used anymore, the clomiphene citrate challenge test is designed to help evaluate your ovarian reserve, or the quality of your eggs. If you do have the test, your doctor will instruct you to take a dose of the medication  Clomid (or as it’s known by its generic name, clomiphene citrate), which helps induce ovulation. You’ll have your blood drawn on day 3 of your cycle to measure levels of follicle-stimulating hormone (FSH) and estradiol (a type of estrogen). Then you’ll take the medication on days 5 through 9. Blood is drawn again on day 10 to measure the same hormones. If your levels are low, that’s a good indication that you have a normal ovarian reserve. If the FSH is still high on day 10, it’s a sign that you may have low ovarian reserve. Note that the test itself isn’t a highly accurate way to predict whether you will get pregnant. It’s more an indicator of whether you may have a problem, and if so, what type of treatment may prove the most helpful.

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