Karlene as a girl's name is a variant of Carlene (Old German), Carly (Latin), Caroline (Old German), Charlotte (Old German), Karleen (English) and Karolina (Slavic), and the meaning of Karlene is "free man".
Popularity Trend Chart
Roll over the visual for detailed rankings by year.
Source: Social Security Administration
Not sure you have the perfect name? Search to add more baby names to your My Favorites list.
Name added. View Your List