Maybe. It depends on your own wants and values—and your budget. The difference between organic cotton and the regular kind is that organic is farmed without the use of pesticides, so it's less likely that chemicals will come into contact with baby's skin if his clothes and sheets are organic. Exactly how much of a pesticide ends up in a finished, regular cotton sheet is hard to gauge, though. And the exact health risks of skin exposure to traces of pesticides aren't really clear. Still, your baby's skin is absorbent, and he'll spend quite a bit of time in his crib—you may feel it's worth it to spend anywhere from 10 percent to 100 percent more for the organic stuff. Knowing your baby will have less potential irritants near his skin could help you rest easier. Also, consider this: Cotton farming accounts for more than 10 percent of the pesticide use in the world. Releasing those toxins into the air, earth and water is considered bad for the environment—another reason you might choose organic.