Hojo

Hojo as a first name is definutely unique. It's primarily known as a surname, made famous by members of a powerful Japanese family. They ruled as regents for the Shoguns in years 1203–1333. As far as regency goes, this family name lasted the test of time. However, more recently, this name was brought back into the limelight as the name of an evil scientist working for Shinra in Final Fantasy VII. If you're looking for a villainous name with a background rooted in real-life history, Hojo might just be the one for you.